Tuberculosis is a major health problem and remains one of the main causes of mortality.\nIn recent years, there has been an increased interest in the pulmonary delivery of antibiotics to treat\ntuberculosis. Isoniazid is one of these antibiotics. In this study, we aimed to characterize isoniazid\nand formulate it into a dry powder for pulmonary administration with little or no excipient, and for\nuse in the disposable Twincer® inhaler. Isoniazid was jet milled and spray dried with and without\nthe excipient l-leucine.............................
Loading....